In some studies, subjects taking capsules made from St. Johns Wort reported better results than subjects taking placebo pills, or even commercial antidepressants.
In other studies, the outcomes were less than or no different than reported results from subjects receiving placebos.
One factor that vexes scientists is determining consistently accurate dosage. Hypericin and hyperforin are the two compounds in St. Johns Wort that are associated with the herb's proven, beneficial effects. Use of dried flowers in powder form is difficult to qualify due to variances in soil structure and growing conditions. Therefore, anecdotal reporting is what continues to fuel the herb's demand.
Regardless of conflicting studies, the overall consensus indicates that hypericin and hyperforin are effective in treating mild to moderate depression and anxiety. And many say that the very sight of the pretty yellow flowers, either encountered in the wild or in a decorative floral arrangement, is enough to brighten one's mood.